The Unexpected Botox Side Effect That’s Leaving Users Shocked—and Shedding Pounds Fast
Ever wonder what happens when Botox and weight loss jabs walk into the same doctor’s office? Well, turns out, quite a few people are scratching their heads over a peculiar side effect when using both treatments simultaneously. Botox, the muscle-relaxing superstar that smooths out wrinkles by blocking nerve signals, usually has us all looking fresh and fabulous for a few months. Meanwhile, weight loss medications like Ozempic and Mounjaro, primarily designed to tackle type 2 diabetes and help shed pounds, seem harmless enough on their own. But combine the two and suddenly, that Botox tightening you used to love feels… well, a bit less tight. Nurse Sam O’Loughlin spills the tea, explaining that shrinking facial fat pads might be the sneaky culprit, making skin look looser so wrinkles peek through even post-Botox. Who knew shedding pounds could mess with your wrinkle game? Intrigued yet? LEARN MORE
It seems a number of people who are using both Botox and weight loss jabs at the same time are complaining about the same side effect.
Botox – which is the brand name for botulinum toxin type A injections – basically works by blocking the signals between nerves and muscles.
Normally, nerves release a chemical called acetylcholine which tells muscles to tighten. Botox stops this chemical from being released, so the muscles relax instead of contracting.
This makes wrinkles look smoother and can also help with medical problems like migraines, muscle spasms, and excessive sweating.
The effects usually last about three to four months, after which the nerves start working normally again.
Ozempic, meanwhile, is a medicine for adults with type 2 diabetes.
Novo Nordisk, who manufacture the drug, previously told LADbible Group that it’s meant to be consumed ‘along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes’.
People are known to have used Botox and weight loss drugs, like Ozempic or Mounjaro, together (Getty Stock Images)
It’s a ‘prescription only medicine and requires a healthcare professional to prescribe under strict supervision’.
And then you’ve got Mounjaro, which can be prescribed as a weight loss drug in the UK, both privately, and under the NHS.
Now, when people have been injecting both Botox and weight loss drugs at the same, nurse Sam O’Loughlin (@itsnursesam) claims they have been complaining about the same side effect.
“So a lot of people when they’re on GLP-one medications or weight loss medications will feel like the Botox isn’t as effective,” she explained in a recent TikTok video.
“They will say that they don’t get the same sort of tightening, they will feel like the movement starts come back a little bit quicker and the results are just not quite what they were prior to starting these medications.”
It is generally considered safe to use Botox and weight loss drugs at the same time (Getty Stock Images)
The health expert from Knutsford says this happens because weight loss reduces facial fat pads, which normally provide support and cushioning under the skin.
When this fat decreases, the skin can look looser or more wrinkled, making fine lines more visible even after Botox.
“Less facial fat means less support, so if your skin is a little bit laxer and a little bit baggier than it was prior to losing weight, after Botox, if you do a big smile, this movement starts to come back you’re gonna see a little bit of wrinkling on the skin because there’s less support,” she said.
People have been complaining about the same side effect (Getty Stock Images)
“Whereas when your face is a little bit fuller you had the cushioning of the fat there which made wrinkles appear less noticeable.”
A spokesperson from Novo Nordisk told LADbible in a statement: “Patient safety is of the utmost importance to Novo Nordisk, and we recommend patients take these medications for their approved indications and under the supervision of a healthcare professional.
“We recommend that any patient experiencing side effects while taking GLP-1 RA medicines, including Wegovy® and Ozempic® (semaglutide injection), report them to their healthcare provider and via the MHRA Yellow Card scheme.”
LADbible Group has contacted Mounjaro’s manufacturer Eli Lilly and Company and Botox’s manufacturer Allergan Aesthetics for comment.
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