Unbelievable Transformations: 20 Celebrities Who Spark Rumors of Ozempic Use—Can You Spot the Difference?

Meghan Trainor has also been open about her experience with weight loss medication, confirming she used Mounjaro after facing changes in her body following pregnancy.

The singer shared the update with fans in March 2025 via Instagram, revealing she had incorporated GLP-1 into her routine as part of a broader health journey.

“I’ve been on a journey to be the healthiest, strongest version of myself for my kids and for me,” she said, explaining that she worked with a dietician.

Trainor, who has spoken candidly about body image struggles throughout her career, emphasized that her focus has shifted from appearance to overall well-being.

She added that being transparent about her experience felt important, especially as conversations around weight-loss medications continue to grow online.

Rosie O’Donnell has confirmed she uses Mounjaro, sharing her experience directly with fans on social media.

In May 2025, the comedian posted on Instagram about her transformation, explicitly referencing the medication in her caption.

“I can’t believe this is me now,” she wrote, adding hashtags including “#mounjaro” and “#weightloss.”

She has previously explained that she takes Mounjaro to manage her diabetes, noting that weight loss came as a side effect alongside lifestyle changes like cutting sugar and drinking mostly water.

In an interview with Us Weekly, the rapper openly discussed incorporating Oz*mpic alongside diet changes to maintain his transformation.

“Oz*mpic says you may only have two pieces of your favorite stuff,” he told US Weekly, explaining how it helped him control portions and cravings.

Fat Joe has shared that he once weighed around 470 pounds and has since lost over 200 pounds over time, crediting a mix of lifestyle changes and medical support.