Unbelievable Transformations: 20 Celebrities Who Spark Rumors of Ozempic Use—Can You Spot the Difference?

Ariana Grande’s “skeletal” appearance has triggered health concerns among fans over the last year.

Many even questioned whether she was relying on the weight loss jabs for her slim, slender appearance. Her recent appearance on the Golden Globes red carpet was no exception to the guesswork about her appearance.

The Side to Side singer recently grew emotional when asked how she “copes” with the constant criticism about her appearance and beauty standards.

“I’ve been kind of doing this in front of the public,” she told a French journalist in December. 

Describing herself as “a specimen in a petri dish” since the age of “16 or 17,” she said: “I have heard it all.”

Sharon Osbourne has not only admitted to taking Ozempic but also said she “went too far” with the medication.

The 72-year-old said it’s “not a sin” to use it and said she lost “three stone [42 pounds] in four months,” which she described as “too much.”

“I don’t know what it’s done to my metabolism, but I just can’t seem to put any [weight] on because I think I went too far,” she said in a podcast with Howie Mandel last year.

Last September, she said she weighed just seven stone and couldn’t put on weight.

“I’m through with the weight loss and all that cosmetic stuff,” she told The Guardian.

Kelly Clarkson’s dramatic weight loss has been the subject of immense speculation.

The singer spoke about losing “a lot” of weight during a conversation with Whoopi Goldberg on The Kelly Clarkson Show.

Whoopi, who has said she takes Mounjaro, spoke to Kelly about “that wonderful shot that works for folks who need some help.”

In response, the American Idol alum said she lost a significant amount of weight with the help of a medication, but she did not specify the details of her prescription.

“Everybody thinks it’s Ozempic. It’s not,” she said.

Rumors about Katy Perry using Ozempic have been rampant in recent months.

“She’s definitely taking Ozempic!” a social media user claimed after her appearance at iHeartRadio Q102’s Jingle Ball in December.

Another agreed saying, “She is on Ozempic; you can not deny the Ozempic face.”

In the same month, she addressed her biceps, which were “going around the internet,” and said she actually hates working out.

“I love to dance, swim, and do things that don’t feel like working out,” she said.

The Fireworks singer herself poked fun at Ozempic rumors during her 40th birthday bash last October.

To her friends who joined her for the birthday celebration, she gave out goodie bags that included an empty mini-syringe emblazoned with the word OzempiKP.

After years of being “exploited” by the tabloids for her weight, Oprah said she turned to an Ozempic-like medication to trim her waistline.

The talk show host, 71, hasn’t specified the brand of the GLP-1 medication she used but said it helped her almost hit her goal weight of 160 pounds (72 kg).

“Every week [I was] exploited by the tabloids; anytime any comedian wanted to make fun or make a joke about it, they would make a joke about it,” she said on her podcast last month.

“And I accepted it because I thought I deserved it,” she added.

Oprah previously said she didn’t want to take medication for weight loss because she felt it was “the easy way out.” But eventually, she released her “own shame about it” and consulted her doctor, who prescribed a weight loss medication.

“I now use it as I feel I need it, as a tool to manage not yo-yo-ing,” she told People in 2023.

John Goodman’s dramatic weight loss transformation raised questions about how he managed to do so.

The onscreen star said he was his heaviest in 2011, weighing 400 lbs, but he managed to shed 200 lbs. However, it took him several years to get there.

“I wanted to do it slowly. Move, exercise,” he told ABC in 2017. I’m getting to the age where I can’t afford to sit still anymore.”

The Emmy winner revealed he cut out alcohol, began following a Mediterranean-style diet, and took at least 10,000 to 12,000 steps a day for his gradual 200-lb weight loss.